Evaluation of Antioxidant and Anticancer Properties of Methanolic Extracts of Abutilon indicum and Blumea mollis

Evaluation of Antioxidant and Anticancer Properties of
Methanolic Extracts of Abutilon indicum and Blumea mollis

Srikanth P, Karthik PS, Sirisha M, Sashikanth Chitti*
Translational Research Institute of Molecular Sciences Pvt.Ltd (TRIMS LABS, 2-35-72,
Sai Narsimha Towers, Sector-10, MVP Colony, Visakhapatnam – 530 017).Andhra Pradesh, India.
Received on:19-01-2012; Revised on: 23-02-2012; Accepted on:27-03-2012

ABSTRACT

Successful plant remedies and their preparations as medicinal treatments have been used for thousands of years in indigenous cultures around the world.Many of today’s valuable drugs such as asprin, digitoxin, morphine and quinine are resulted from traditionally used plants after scientific evaluation. In the present study medicinal plants namely Abutilon indicum and Blumea mollis were chosen to screen for potential anti-oxidant properties and cytotoxic activity. The concentration of phenol was determined using Folin-Ciocalteu assay (26) with minor modifications. The extract was also screened to assess the antioxidant activity using FRAP, 1, 1-Diphenyl-2-picrylhydryzyl [DPPH] radical scavenging activity and Nitric Oxide radical inhibition estimated by the use of Griess Illosvoy reaction (6) with slight modification. These extracts show anti-oxidant properties as well as inhibitory effect on cancer cells with the increased concentration and duration. When used in higher concentrations, these extracts show good inhibition rates which might prove to be effective for the prevention of cancer.

Keywords: Abutilon indicum; Blumea mollis; Antioxidant properties; Cytotoxic activity; DPPH; MEM

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