Correlation between vitamin D3 serum levels and subsequent
incidence of Type 1 diabetes. The six-year study of blood levels of nearly
2,000 individuals suggests a preventive role for vitamin D3 in this disease.
The research appears the December issue ofDiabetologia, a publication of
the European Association for the Study of Diabetes (EASD). (Eagle Group- Nov 15, 2012)
"Previous studies proposed the existence of an association
between vitamin D deficiency and risk of and Type 1 diabetes, but this is the
first time that the theory has been tested in a way that provides the
dose-response relationship," said Cedric Garland, DrPH, FACE, professor in
UCSD's Department of Family and Preventive Medicine.
This study used samples from millions of blood serum specimens
frozen by the Department of Defense Serum Registry for disease surveillance.
The researchers thawed and analyzed 1000 samples of serum from healthy people
who later developed type 1 diabetes and 1000 healthy controls whose blood was
drawn on or near the same date but who did not develop type 1 diabetes. By
comparing the serum concentrations of the predominant circulating form of
vitamin D -- 25-hydroxyvitamin D (25(OH)D) -- investigators were able to
determine the optimal serum level needed to lower an individual's risk of
developing type 1 diabetes.
Based mainly on results of this study, Garland estimates that the
level of 25(OH)D needed to prevent half the cases of type 1 diabetes is 50
ng/ml. A consensus of all available data indicates no known risk associated
with this dosage.
"While there are a few conditions that influence vitamin D
metabolism, for most people, 4000 IU per day of vitamin D3 will be needed to
achieve the effective levels," Garland suggested. He urges interested
patients to ask their health care provider to measure their serum 25(OH)D
before increasing vitamin D3 intake.
"This beneficial effect is present at these intakes only for
vitamin D3," cautioned Garland. "Reliance should not be placed on
different forms of vitamin D and mega doses should be avoided, as most of the
benefits for prevention of disease are for doses less than 10,000 IU/day."
Garland's co-authors from UC San Diego School of Medicine and the
Naval Health Research Center include Edward Gorham, PhD; Sharif Mohr, PhD; and
Heather Hofflich, DO; Alina Burgi and Kenneth Zeng of the Naval Health Research
Center, and Camillo Ricordi MD, of the University of Miami Diabetes Research
Institute.
The study was supported by a Congressional allocation to the
Diabetes Research Institute of the University of Miami through the Naval Health
Research Center, San Diego, California.
Source:
The above story is reprinted from materials provided
by University of California, San Diego Health Sciences.
Note: Materials may be edited for content and length.
For further information, please contact the source cited above.
Journal Reference:
1. E. D. Gorham, C. F. Garland, A. A. Burgi, S. B.
Mohr, K. Zeng, H. Hofflich, J. J. Kim, C. Ricordi. Lower prediagnostic
serum 25-hydroxyvitamin D concentration is associated with higher risk of
insulin-requiring diabetes: a nested case–control study.Diabetologia,
2012; 55 (12): 3224 DOI: 10.1007/s00125-012-2709-8
Disclaimer: This article is not intended to provide
medical advice, diagnosis or treatment. Views expressed here do not necessarily
reflect those of Eagle Group or its staff.
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