As HIV transmission is reported to
be “out of control” among gay men in France, Israeli researchers offer hope
against the spread of the AIDS virus. A new treatment discovered at the Hebrew
University’s Alexander Silberman Institute of Life Sciences and the Institute
of Chemistry may have the ability to destroy HIV-infected human cells without
damaging healthy ones.
Treatment
Causes Infected Cells to Self-Destruct
Currently, there is no cure for AIDS,
however current treatments have been developed to delay the development of the
disease and make it more manageable. The new treatment fights HIV by causing
infected cells to “self-destruct”, says Dr. Abraham Loyter who published his
findings in the British journal AIDS Research and Therapy.
When the Human Immunodeficiency
Virus (HIV) enters a cell, its DNA replicates which manufactures new virus that
infects surrounding cells. The peptide treatment discovered by Dr. Loyter and
his colleagues will interfere with this genetic replication by transmitting a
signal to kill the infected cell. In human cell laboratory cultures, the
infected cells disappeared in two weeks and did not reappear up to two weeks
later.
The treatment developed by the team
was patented earlier this year and they plan to start animal and human trials
soon.
It is estimated that about 33 million people worldwide are
carriers of HIV with the majority of those affected living in Sub-Saharan
Africa. In the US, one million are estimated to be living with the virus while
another half million have died. The latest figures from France, reported in the
Lancet Infectious Disease journal, has found that 7,000 new cases of HIV were
diagnosed in 2008 in France, nearly half of those in homosexual men.
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